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September2004 Vol.41 Issue:      3 (Supp.) Table of Contents
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Memory in Normal Elderly Egyptians: Neuropsychological and Radiological Assessment

Maged Abdel-Naseer1, Fadia Elwan2, Mamdouh Mahfouz3


Departments of Neurology1, Clinical Psychology2, Radiology3, Cairo University


One hundred and four adult Egyptian subjects (78 males and 26 females) were evaluated using neuropsychological rating scales and brain CT scan. The age of the studied sample ranged from 40 to 82 years with a mean of 59.4 ±8.2 years. They were classified -according to memory impairment- into 2 groups: Group A: (without objective memory test impairment) and Group B: (with objective memory test impairment). This group was further subdivided into: B1 (with additional subjective forgetfulness complaints) and B2 (without subjective complaints regarding forgetfulness). The subjects were assessed neuropsychologically using Minimental State Examination (MMSE), Sandoz Clinical Assessment Geriatric scale (SCAG), Global Deterioration Scale (GDS), and Clinical Dementia Rating scale (CDR). Moreover, certain brain CT measures were evaluated including maximal bifrontal distance (F), bifrontal index (FI), maximal bicaudate distance (C), bicaudate index (CI), and maximum width of the 3rd ventricle (V3). The study revealed that Group B subjects were significantly older than Group A. In addition, Group B1 subjects were older than Group B2.  Regarding neuropsychological results, Group B subjects scored worse than Group A in all tested scales (MMSE, SCAG, GDS, and CDR). However, results were statistically significant as regard MMSE and SCAG. Moreover, Group B1 subjects scored significantly worse than B2 subjects in all tests (MMSE, SCAG, GDS, and CDR). Group B subjects had increased size of the 3rd ventricle on brain CT scans. Besides, both bicaudate distance (C) and index (CI) were significantly increased in Group B1 subjects when compared with Group B2 indicating some sort of subcortical atrophy in Group B1 subjects. In conclusion, neuropsychological assessment and brain CT scan could be considered as valuable tools for detection of early and mild cognitive impairment before development of dementia.

(Egypt J. Neurol. Psychiat. Neurosurg., 2004, 41 (3) suppl.: 845-852).


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