Background: Multiple sclerosis (MS)
is a multifactorial demyelinating immune- mediated neurological disease.
It is currently not clear if altered levels of prolactin documented in MS
patients are a primary phenomenon in the pathogenesis of the disease. Objective: To evaluate possible
correlations of Prolactin level with different clinical presentations of the
disease. Methods: Thirty-four MS patients were compared to 30 age and sex
matched controls regarding PRL level. Situations that may alter PRL level were
excluded. Correlations of other variables were done as duration of illness;
Expanded Disability Status Scores (EDDS), MS type. Results: There was no
statistically significant difference between patients and controls regarding
prolactin level. In addition, there were no statistically significant
differences between patients with higher prolactin level and those with normal
level regarding age, gender, type of disease, EDDS and duration of disease.
Correlation analysis confirmed significant dual influence between disease
duration and EDDS and age versus disease duration. Conclusion: Results
suggest no association between elevated titers of prolactin and types of
multiple sclerosis. Prolactin might not be involved in the pathogenesis of
multiple sclerosis but might be coexisting with or a consequence of central
nervous system (CNS) demyelination in MS. [Egypt
J Neurol Psychiat Neurosurg. 2015; 52(2): 153-157]
Key Words: Prolactin, MS
Correspondence to Tamer Belal Address:
Neurology department, Mansoura
University, Egypt.
Tel: +0201000921279 Email:
tamr200@yahoo.com