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April2015 Vol.52 Issue:        2        Table of Contents
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Serum Prolactin Level in Patients with Multiple Sclerosis

Tamer Belal1, Ashraf El-Mitwalli1, Amany El-Diasty2, Azza El Mongui1

Departments of Neurology1, Clinical Pathology2, Mansoura University; Egypt



ABSTRACT

Background: Multiple sclerosis (MS) is a multifactorial demyelinating immune- mediated neurological disease. It is currently not clear if altered levels of prolactin documented in MS patients are a primary phenomenon in the pathogenesis of the disease. Objective: To evaluate possible correlations of Prolactin level with different clinical presentations of the disease. Methods: Thirty-four MS patients were compared to 30 age and sex matched controls regarding PRL level. Situations that may alter PRL level were excluded. Correlations of other variables were done as duration of illness; Expanded Disability Status Scores (EDDS), MS type. Results: There was no statistically significant difference between patients and controls regarding prolactin level. In addition, there were no statistically significant differences between patients with higher prolactin level and those with normal level regarding age, gender, type of disease, EDDS and duration of disease. Correlation analysis confirmed significant dual influence between disease duration and EDDS and age versus disease duration. Conclusion: Results suggest no association between elevated titers of prolactin and types of multiple sclerosis. Prolactin might not be involved in the pathogenesis of multiple sclerosis but might be coexisting with or a consequence of central nervous system (CNS) demyelination in MS. [Egypt J Neurol Psychiat Neurosurg.  2015; 52(2): 153-157]

 Key Words: Prolactin, MS

Correspondence to Tamer Belal Address: Neurology department, Mansoura University, Egypt.

Tel: +0201000921279   Email:  tamr200@yahoo.com





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