Background: There is accumulating evidence that inflammation can cause
seizure and seizure can cause brain inflammation perpetuating antiepileptic
drug refractoriness in patients with epilepsy. Objective: This study aims to test the pro-inflammatory
interleukin-1beta response to seizure in patients with idiopathic epilepsy. Methods: Fifty-six patients with idiopathic generalized epilepsy
were included in the study during their hospitalization for seizure management
and their interleukin -1beta were assessed within 6-hours of the index seizure
by ELIZA (Enzyme Linked Immunosorbent Assay). Another assessment was done in 20
patients after 24-hours of the index seizure. Results: Interleukin-1beta was increased significantly within
6-hours and dropped significantly in the twenty patients after 24-hours of the
index seizure (P<0.001*). The 24-hours assay is still significantly higher
than normal population (P=0.003*). This increased was not significantly
different by seizure frequency, number of antiepileptic drugs or duration of
epilepsy. Conclusion: Seizures do increase
interleukin-1beta and the later might have a role in seizure generation in
idiopathic generalized epilepsy. [Egypt
J Neurol Psychiat Neurosurg. 2015; 52(2): 83-86]
Key Words: Interleukin-1beta, seizure, idiopathic
epilepsy.
Correspondence to Ibrahim Elmenshawi. Neurology Department, Mansoura University, Egypt.
Tel.:
+201005447704
Email:menshawy@mans.edu.eg