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April2015 Vol.52 Issue:        2        Table of Contents
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Seizure-induced Interleukin-1beta Assay in Idiopathic Generalized Epilepsy

Ahmed Aladawy1, Ibrahim Elmenshawi1, Youssef M Mosaad2, Mohammad S. Shehab-Eldeen1

Departments of Neurology1, Clinical Pathology2, Mansoura University; Egypt


Background: There is accumulating evidence that inflammation can cause seizure and seizure can cause brain inflammation perpetuating antiepileptic drug refractoriness in patients with epilepsy. Objective: This study aims to test the pro-inflammatory interleukin-1beta response to seizure in patients with idiopathic epilepsy. Methods: Fifty-six patients with idiopathic generalized epilepsy were included in the study during their hospitalization for seizure management and their interleukin -1beta were assessed within 6-hours of the index seizure by ELIZA (Enzyme Linked Immunosorbent Assay). Another assessment was done in 20 patients after 24-hours of the index seizure. Results: Interleukin-1beta was increased significantly within 6-hours and dropped significantly in the twenty patients after 24-hours of the index seizure (P<0.001*). The 24-hours assay is still significantly higher than normal population (P=0.003*). This increased was not significantly different by seizure frequency, number of antiepileptic drugs or duration of epilepsy. Conclusion: Seizures do increase interleukin-1beta and the later might have a role in seizure generation in idiopathic generalized epilepsy. [Egypt J Neurol Psychiat Neurosurg.  2015; 52(2): 83-86]


Key Words: Interleukin-1beta, seizure, idiopathic epilepsy.

Correspondence to Ibrahim Elmenshawi. Neurology Department, Mansoura University, Egypt.

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