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January2015 Vol.52 Issue:        1        Table of Contents
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Cerebral Small Vessel Disease and Cognition

Omar El Serafy1, Mohammed El Sayed Al Awwady1,

Mona AF Nada1, Amr Hassan1, Ahmed Reda2

Department of Neurology, Cairo University1, Om Al Masryeen Hospital2, Ministry of Health; Egypt


Background: Cerebral small vessel disease (SVD) is one of the frequent findings on CT and MRI scans of elderly people and is related to vascular risk factors, cognitive and motor impairment. Objective: The objective of the present study is to evaluate cognitive impairment associated with small vessel disease. Methods: This is a case-control study where consecutive non-demented patients with confluent leukoaraiosis on MRI were recruited to assess the cognitive impairment associated with SVD (n = 40), and underwent neuropsychological assessment and multimodal brain MRI. Control group included healthy volunteers who were age, sex and education level matched (n=10). Results: The performance of the patient group was lower than the control group in Addenbrooke test, verbal fluency test, trail making B test, Digit symbol test (DST), Paired Associate Learning Test (PALT) and block design test and these statistical differences were highly significant (P-value < 0.01), a statistically significant difference between the 2 groups was also found in trail making A test (P-value < 0.05). The duration of the vascular risk factors of the SVD (hypertension and diabetes mellitus) and the grades of Fazeka's scale were negatively correlated with the performance of the patient group in all of the cognitive tests Conclusion: Cerebral Small vessel disease is associated with cognitive impairment affecting mainly verbal fluency, language skills and executive functions. [Egypt J Neurol Psychiat Neurosurg.  2015; 52(1): 75-82]


Key Words: Small vessel disease, vascular cognitive impairment

Correspondence to Amr Hasan El Sayed Mohammed, Neurology Department, Cairo University.Tel.: +201006060809.  Email:

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