Online ISSN : 1687-8329


Quick Search 

January2015 Vol.52 Issue:        1        Table of Contents
Full Text

Restless Leg Syndrome in a Sample of Egyptian Patients with Multiple Sclerosis

Lobna M. El-Nabil1, Noha Lotfy1, Naglaa Elkhayat1, Khaled O. Abdulghani2,

Magdy Ahmed1, M. Ossama Abdulghani1

Department of Neurology, Ain Shams University1, Helwan University2; Egypt


Background: Restless leg syndrome (RLS) has been described to be common in multiple sclerosis (MS). However, the relationship between RLS and sleep quality, fatigue and clinical disability in MS patients has not been fully investigated. Objective: To study the frequency of RLS in a sample of Egyptian patients with MS and if it correlates with magnetic resonance imaging (MRI) findings. Methods: We studied fifty patients with MS compared to thirty healthy volunteers who matched patients group for age and sex as a control group. The patient group was subjected to full clinical and neurological assessment, including the diagnosis of RLS, neurological impairment was evaluated by multiple sclerosis severity scale (MSS), fatigue Descriptive Scale (FDS) for assessment of fatigue, quality of sleep by the Pittsburgh Sleep Quality Index (PSQI), Epworth sleepiness scale (ESS), and MRI of the brain and spinal cord were done. Results: Our results showed that RLS frequency among our sample was 20%, which is higher than control group (6.66%), and revealed that there is affection of sleep quality among RLS positive patients in comparison to RLS negative patients in which their PSQI and ESS are higher among RLS positive group. Regarding MRI lesion, there was no statistically significant difference between MS patients with RLS and those without. Conclusion: RLS is significantly associated with MS and can lead to sleep disturbance in MS patients. In clinical practice, the routine screening of patients for insomnia and symptoms of RLS is encouraged. [Egypt J Neurol Psychiat Neurosurg.  2015; 52(1): 55-61]

Key Words: Restless Leg Syndrome, MS, Epworth sleepiness scale, PSQI

Correspondence to Lobna Mohammad Elnabil, Department of Neurology, Ain Shams University; Egypt. Tel: +201001120127, Email: 

2008 � Copyright The Egyptian Journal of Neurology,
Psychiatry and Neurosurgery. All rights reserved.

Powered By DOT IT