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Restless Leg Syndrome in a Sample of Egyptian Patients with Multiple Sclerosis
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Lobna M.
El-Nabil1, Noha Lotfy1, Naglaa Elkhayat1,
Khaled O. Abdulghani2,
Magdy Ahmed1,
M. Ossama Abdulghani1
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Department
of Neurology, Ain Shams University1, Helwan University2; Egypt
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ABSTRACT
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Background: Restless leg syndrome (RLS) has been described to be
common in multiple sclerosis (MS). However, the relationship between RLS and
sleep quality, fatigue and clinical disability in MS patients has not been
fully investigated. Objective: To study the frequency of RLS in a sample
of Egyptian patients with MS and if it correlates with magnetic resonance
imaging (MRI) findings. Methods: We studied fifty patients with MS
compared to thirty healthy volunteers who matched patients group for age and
sex as a control group. The patient group was subjected to full clinical and
neurological assessment, including the diagnosis of RLS, neurological
impairment was evaluated by multiple sclerosis severity scale (MSS), fatigue
Descriptive Scale (FDS) for assessment of fatigue, quality of sleep by the
Pittsburgh Sleep Quality Index (PSQI), Epworth
sleepiness scale (ESS), and MRI of the brain and spinal cord were done. Results:
Our results showed that RLS frequency among our sample was 20%, which is higher
than control group (6.66%), and revealed that
there is affection of sleep quality among RLS positive patients in comparison
to RLS negative patients in which their PSQI and ESS are higher among RLS
positive group. Regarding MRI lesion, there was no statistically significant
difference between MS patients with RLS and those without. Conclusion:
RLS is significantly associated with MS and can lead to sleep disturbance in MS
patients. In clinical practice, the routine screening of patients for insomnia
and symptoms of RLS is encouraged. [Egypt J Neurol
Psychiat Neurosurg. 2015; 52(1): 55-61]
Key
Words: Restless Leg Syndrome, MS, Epworth sleepiness scale, PSQI
Correspondence to Lobna Mohammad Elnabil, Department of
Neurology, Ain Shams University;
Egypt.
Tel: +201001120127, Email: lobna_alnabil@yahoo.com
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