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October2014 Vol.51 Issue:        4        Table of Contents
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Abnormal Brain Morphology in Primary Microcephalic Children with Different Etiologies

Maha A. Nada1, Samia A. Helal1, Lobna M. El-Nabil1, Ahmed M. Samy2,

Nagwa A. Mohamed2, Ahmad M. Aboul Fotouh3

Departments of Neurology, Ain Shams University1, National Research Center2;

Radiology3, Al-Azhar University; Egypt


Background: Microcephaly is evident upon physical examinations but the spectrum of brain malformations associated with different forms of microcephaly can only be diagnosed by brain imaging which help definite diagnosis, prognosis and genetic counseling. Objective: To assess the relationship between brain morphology and microcephaly of different etiologies. Methods: We recruited 20 children with microcephaly (10 males and 10 females) and seventeen healthy age and sex-matched children were enrolled in the study as control group; they were assessed by detailed history taking including three generation pedigree and thorough clinical examinations. They were all subjected to MRI with quality control analysis. MRI analysis was performed to cases and controls in order to measure the following cortical thickness (CTH), cortical volume (CV), cortical Surface Area (SA), gyrification index measurement (GI) and cortical complexity (CC). Results: There was statistical significant difference between different groups with microcephaly in its whole (CTh) and in different lobes. While no significant difference in different groups regarding the whole and different lobes (SA). Also there was no significant statistical difference of brain (CV) in different groups of microcephaly. The degree of (CC) showed significant statistical difference between different groups in some lobes. However, there was no difference of (GI) in different groups of microcephaly. Conclusion: In different groups of microcephaly, there is significant difference in CTh, and some lobes CC. Additional significant statistical decreases of some MRI measures were found in the results of some groups of microcephaly when compared to control group. [Egypt J Neurol Psychiat Neurosurg.  2014; 51(4): 375-380]

 Key Words: Microcephaly, brain morphology, different etiology.

Correspondence to Maha A. Nada, Department of Neurology, Ain Shams University, Egypt. Email:

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