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July2014 Vol.51 Issue:        3       (Supp.) Table of Contents
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Efficacy and Attributes of Repetitive Transcranial Magnetic Stimulation (rTMS) in Treatment of a Sample of Children with Attention Deficit Hyperactivity Disorder (ADHD)

Iman M. Bayoumy1, Salma H. Khaleel1, Maha Nada1, Mona Ibraheem Awaad2,

Doaa Khalifa2, Hesham Hatata2

Departments of Neurology1, Psychiatry2, Ain Shams University; Egypt



ABSTRACT

Background: Attention deficit hyperactivity disorder (ADHD) is a syndrome that affects children. Repetitive transcranial magnetic stimulation (rTMS) can produce effects on dopaminergic system similar to effects of D-amphetamine. Objective: To evaluate efficacy of rTMS as a therapeutic modality in ADHD in children. Methods: This study was conducted on 41 ADHD children. All patients were subjected to clinical psychiatric and psychometric assessment using Kiddie Schedule, Wechsler Intelligence Scale and Conners’ Parent Rating Scale Revised Long-version (CPRS-R-L). Neurological assessment by diagnostic TMS, Physical and Neurological Examination for Soft Signs (PANESS) scale for neurological soft signs, and conventional EEG were done before and after rTMS given at low frequency 1Hz, 1200stimuli/day for five days. Results: EEG showed increased beta activity in 26 cases (63.4%) after rTMS. Highly significant reductions were found in all studied dimensions except perfectionism scale and psychosomatic scale. Females showed higher percent of change in psychosomatic subscale and ipsilateral silent period (ISP) latency. Boys showed significant reduction of oppositional attitude and hyperactivity. Hyperactivity and ISP duration showed significant correlation with older ages. Highly significant difference in the anxious shy was found in the inattentive subtype. Social problems showed significant change in the combined type. Psychosomatic dimension was significantly increased in the inattentive compared to combined type. ISP latency showed significant change on correlating inattentive with hyperactive impulsive type. Conclusion: Most of the used tests showed significant results but the higher difference in diagnostic TMS and PANESS scale makes them superior over psychometric tests in evaluating rTMS therapy. [Egypt J Neurol Psychiat Neurosurg.  2014 ; 51(3): 361-367]


Key Words: ADHD, rTMS, diagnostic TMS, Conners scale, Kiddie schedule, PANESS scale.

 Correspondence to Iman Bayoumy, Neurology Department, Ain Shams University, Egypt. Tel.: +201002595522.       Email: imanbayomy@yahoo.com






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