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July2014 Vol.51 Issue:        3       (Supp.) Table of Contents
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Effect of Prophylactic Treatment on Visual Evoked Potentials (P100) in Migraineurs

Mamdouh Ali Kotb1, Sayed Sobhy2, Nermine Ali Hamdi1

Department of Neurology, Elminia University1; Fayoum University2; Egypt


Background: Migraine is a common neurovascular disorder. Visual evoked potential (VEP) changes, between migraineurs and normal subjects, were often conflicting. Objective: Compare VEP (P100) in patients with migraine with and without aura to normal subjects, and the effect of prophylactic treatment. Methods: Visual evoked potential was recorded in 32 patients with migraine and 15 healthy control subjects. Results: P100 amplitude was significantly higher and its latency was significantly longer in patients with migraine compared to control subjects, this difference disappeared in patients with regular prophylactic treatment. Conclusion: Cortical excitability changes may be related to the pathophysiology of migraine and the efficacy of prophylactic treatment. [Egypt J Neurol Psychiat Neurosurg.  2014; 51(3) : 321-326]

Key words: Visual evoked potential, P100, migraine.

Correspondence to  Sayed Sobhy,2 Department of Neurology, Fayoum University, Fayoum. Egypt. Tel.: +01222190502.     Email:

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