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July2014 Vol.51 Issue:        3       (Supp.) Table of Contents
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A Study of the Preclinical Stages of Diabetic Retinopathy Using Multifocal Electroretinography

Gehad A. Elnahri1, Zeinab S. Elsanabary1, Amira M. El Gohary2, Ghada A. Ismaiel3

Departments of Ophthalmology1, Clinical Neurophysiology2, Cairo University;

Ophthalmic Diagnostic Laser Unit, Cairo University Hospitals3; Egypt


Background: Diabetes-related eye disease is the most common cause of loss of vision in developed countries. Objective: To evaluate the changes of the multifocal electroretinography (mfERG) in the preclinical stage of diabetic retinopathy as a predictor of early onset of diabetic retinopathy. Methods: mfERG was recorded in 37 eyes of normal controls and 51 eyes of 26 diabetic patients without retinopathy. The diabetic patients with at least 5 years of diabetes were enrolled after examination by fundus biomicroscopy and fluorescein angiography. Quadrant analysis of the amplitude and implicit time of P1 wave of the mfERG was used to compare between patient groups and controls. Results: The mean implicit time of the response in the lower temporal quadrant was significantly different between both diabetic and normal groups. The mean amplitude of the foveal response was significantly decreased in the diabetic group than in the normal group. The implicit time of the response in the diabetic group increased with the age of the patients and the duration of the diabetes. The glycemic control status did not correlate with the local mfERG responses. Conclusions: The mfERG peak time is a promising predictor for the development of diabetic retinopathy together with the duration of diabetes; especially in preclinical cases. A longitudinal prospective study may be required to confirm the findings of this study. [Egypt J Neurol Psychiat Neurosurg.  2014; 51(3): 255-263]


Key Words: Preclinical diabetic retinopathy - quadrant analysis - multifocal electroretinography - diabetic retinopathy predictors.

Correspondence to Amira M. El Gohary, Department of Clinical Neurophysiology, Cairo University.


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