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April2014 Vol.51 Issue:        2        Table of Contents
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Radiologically Isolated Syndrome and its Possibility for Clinical Conversion to Multiple Sclerosis

  Wael A. Fadel, Wafik S. Bahnasy, Ehab A. El-Seidy, Yasser A. El-Heneedy,

Tarek M. El-Gammal, Khaled H. Rashed

Department of Neuropsychiatry, Tanta University; Egypt


Background: There is increasing incidence of abnormal MRI findings suggestive of multiple sclerosis (MS) in persons without MS symptoms, which is termed as radiologically isolated syndrome (RIS). These RIS people have increased incidence of clinical conversion to MS. Objective: To follow up a group of RIS persons both clinically and by some investigations to assess the possibility of conversion to MS. Methods: This study included 28 RIS patients who were followed up by clinical examination, brain and cervical MRI and visual evoked potential (VEP) for early detection of the development of clinical conversion to MS. Results: Six of 28 cases of RIS persons (21.4%) developed clinical manifestations of MS within 2 years follow up. Mean age of clinically converted cases were 22.6 years (SDĀ±1.3), 5 patients were female, 2 patients had cervical MRI lesions, 4 patients had infratentorial MRI lesions and 4 patients had delayed P100 of VEP study. Conclusion: Patients with RIS are at high risk of developing clinical manifestations of MS especially those with baseline younger age, female sex, presence of periventicular high lesion number, cervical, infratentorial lesions and abnormally delayed VEP. [Egypt J Neurol Psychiat Neurosurg.  2014; 51(2): 229-234]


Key Words: Radiologically Isolated Syndrome, RIS, Multiple Sclerosis, MRI and Visual Evoked Potential, VEP.

Correspondence to Wafik S. Bahnasy, Department of Neuropsychiatry Tanta University, Egypt.Tel: +201060637106. Email:

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