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Radiologically Isolated Syndrome and its Possibility for Clinical Conversion to Multiple Sclerosis
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Wael A. Fadel, Wafik S. Bahnasy, Ehab
A. El-Seidy, Yasser A. El-Heneedy,
Tarek M. El-Gammal, Khaled H.
Rashed
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Department of Neuropsychiatry, Tanta
University; Egypt
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ABSTRACT
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Background:
There is increasing incidence of abnormal MRI findings suggestive of multiple
sclerosis (MS) in persons without MS symptoms, which is termed as
radiologically isolated syndrome (RIS). These RIS people have increased incidence
of clinical conversion to MS. Objective:
To follow up a group of RIS persons both clinically and by some investigations
to assess the possibility of conversion to MS. Methods:
This study included 28 RIS patients who were followed up by clinical examination,
brain and cervical MRI and visual evoked potential (VEP) for early detection of
the development of clinical conversion to MS. Results:
Six of 28 cases of RIS persons (21.4%) developed clinical manifestations of MS
within 2 years follow up. Mean age of clinically converted cases were 22.6
years (SD±1.3), 5 patients were female, 2 patients had cervical MRI lesions, 4
patients had infratentorial MRI lesions and 4 patients had delayed P100 of VEP
study. Conclusion: Patients with RIS are
at high risk of developing clinical manifestations of MS especially those with
baseline younger age, female sex, presence of periventicular high lesion
number, cervical, infratentorial lesions and abnormally delayed VEP. [Egypt
J Neurol Psychiat Neurosurg. 2014; 51(2): 229-234]
Key Words: Radiologically
Isolated Syndrome, RIS, Multiple Sclerosis, MRI and Visual Evoked Potential,
VEP.
Correspondence
to Wafik S. Bahnasy, Department of Neuropsychiatry
Tanta University, Egypt.Tel:
+201060637106. Email: wafikbahnasy@gmail.com
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