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January2014 Vol.51 Issue:        1        Table of Contents
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Relation between Serum Vitamin D Levels and Activity of Multiple Sclerosis


Mamdouh Ali Kotb1,3, Sayed Sobhy Sayed2,4


Departments of Neurology, El-Minia University1, Fayoum University2; Egypt

National Hospital3, Al-Mousa Hospital4; Saudi Arabia


Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system. Vitamin D level affects the risk of MS onset. Objective: To evaluate the effect of vitamin D level on the clinical course of the disease. Methods: Twenty-two MS patients followed for one year. Clinical evaluation, serum 25 hydroxyvitamin D level measurement, and MRI evaluation were done for all patients. Results: Patients with MS had vitamin D insufficiency. Patients with confirmed relapses had significantly lower serum vitamin D compared to patients without relapses. Serum vitamin D level inversely correlates with the clinical severity of the disease. Conclusion: Vitamin D has a role in the clinical course and severity of MS disease. [Egypt J Neurol Psychiat Neurosurg.  2014; 51(1): 123-129]


Key Words: Vitamin D, multiple sclerosis, vitamin D deficiency.

Correspondence to Sayed Sobhy Sayed, Department of Neurology, Fayoum University, Egypt.

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