Background:
Multiple sclerosis (MS) is a chronic disease of the central nervous system.
Vitamin D level affects the risk of MS onset. Objective: To evaluate the effect
of vitamin D level on the clinical course of the disease. Methods:
Twenty-two MS patients followed for one year. Clinical evaluation, serum 25
hydroxyvitamin D level measurement, and MRI evaluation were done for all
patients. Results:
Patients with MS had vitamin D insufficiency. Patients with confirmed relapses
had significantly lower serum vitamin D compared to patients without relapses.
Serum vitamin D level inversely correlates with the clinical severity of the
disease. Conclusion:
Vitamin D has a role in the clinical course and severity of MS disease. [Egypt J Neurol Psychiat Neurosurg. 2014; 51(1): 123-129]
Key Words:
Vitamin D, multiple sclerosis, vitamin D deficiency.
Correspondence to Sayed Sobhy Sayed, Department
of Neurology, Fayoum University,
Egypt.
Tel: +201222190502 Email: sobhysayed@hotmail.com