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October2013 Vol.50 Issue:        4        Table of Contents
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Temporal lobe Epilepsy: Correlation between Electroencephalography and Magnetic Resonance Spectroscopy

Sabah M. Lotfy1, Heba A. Selim1, Hanan Salah1, Seham F. Abd Elhamed2,

Ghada Abdulmoneem3, Enass M. Khattab3

Departments of Neurology1, Pediatrics2, Radiodiagnosis3, Zagazig University; Egypt



ABSTRACT

Background: Patients with temporal lobe complex partial seizures constitutes the majority of patients referred for surgical consideration. Objective: Our study was designed to evaluate the ability of magnetic resonance spectroscopy in detecting the side of the epileptic focus in patients with temporal lobe epilepsy in relation to electroencephalography. Methods: 29 patients with non-lesional temporal lobe epilepsy and 14 healthy volunteers as a control group were included in our study. All patients were subjected to clinical examination, interictal electroencephalography and magnetic resonance imaging. Proton magnetic resonance spectroscopic examination was performed to the patients and the controls. Results: According to the findings of electroencephalography, our patients were classified to three groups: Group 1 consisted of 16 patients with unitemporal (lateralized) epileptic focus, group 2 consisted of 8 patients with bitemporal (non-lateralized) epileptic focus and group 3 consisted of 5 patients with normal electroencephalography. Magnetic resonance spectroscopy could lateralize the epileptic focus in 15 patients in group 1, six patients in group2 and three patients in group 3 with overall lateralization of (82.75%), while electroencephalography was able to lateralize the focus in (55.17%) of patients and magnetic resonance imaging detected lateralization of mesial temporal sclerosis in 58.6% of patients. Conclusion: Magnetic resonance spectroscopy is a promising tool in evaluating patients with epilepsy and offers increased sensitivity to detect temporal pathology that is not obvious on structural MRI imaging. [Egypt J Neurol Psychiat Neurosurg.  2013; 50(4): 441-448] 

Key Words: Temporal lobe epilepsy, Electroencephalography, Magnetic resonance spectroscopy.

Correspondence to Sabah M. Lotfy, Department of Neurology, Zagazig University, EgyptTel.: +201224819019. email: dr.sabahlotfy67@yahoo.com





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