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April2013 Vol.50 Issue:        2        Table of Contents
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Pattern of Optical Coherence Tomography in Multiple Sclerosis

Dina Abdel Gawad Zamzam1, Ahmed Taha Ismail2, Amr Abdel Moneim1, Ahmed Elbassiouny1

Departments of Neurology1, Ophthalmology2; Ain Shams University; Egypt

 



ABSTRACT

Background: Optic neuritis (ON) is strongly associated with multiple sclerosis (MS). Optical coherence tomography (OCT) has the potential to provide a reliable means of capturing axonal deficits, which can be paired to tests of visual function to provide a structural functional paradigm of brain injury. Objective: We aimed to evaluate retinal nerve fibre layer (RNFL) and total macular volume (TMV) thickness in MS patients with and without optic neuritis, and to correlate our findings with clinical measures of disability and MRI findings. Methods: Forty patients with MS were recruited from the outpatient clinics and the Neurology Department at Ain Shams University hospitals, with age range 16-53 years, with and without optic neuritis and 16 age and sex matched healthy controls were enrolled in this study. All patients were subjected to history, clinical evaluation, extended disability status scale (EDSS) for disease severity, MRI brain with contrast, visual evoked potential (VEP) and high-resolution spectral-domain OCT to assess the RNFL and TMV of the optic nerve. The control group performed OCT. Results: RNFL and TMV thinning was significantly correlated with the MS group in all field sectors with and without ON, compared to the control group. No correlation was found between OCT and VEP among MS group. TMV was inversely correlated with MRI finding in contrast to RNFL, where no correlation was found. Conclusion: RNFL and TMV thickness was significantly decreased in MS with and without ON. In addition, there were significant differences in RNFL and TMV thickness within field quadrants. [Egypt J Neurol Psychiat Neurosurg.  2013; 50(2): 205-212]

 Key Words: Optical coherence tomography, Retinal nerve fibre layer, MS, Optic neuritis.

Correspondence to Dina Abdelgawad Zamzam. Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt. e-mail: Dina.zamzam@hotmail.com.





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