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April2013 Vol.50 Issue:        2        Table of Contents
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Role of Serum and Cerebrospinal Fluid Cytokines in Differentiation of Vascular Cognitive Impairment and Mild Cognitive Impairment

Mohamed S. El-Tamawy1, Tarek Z. Tawfik1, Shereen Fathy1, Reem J. Farid2,

Sandra M. Ahmed1, Gihan A. Sleem3, Yasmine S. Kamal1

Departments of Neurology1, Clinical Patholology2, Internal Medicine3; Cairo University; Egypt


Background: Although Alzheimer’s (AD) dementia was considered to be the most common form of dementia, vascular cognitive impairment has been found to be more common than previously thought. Inflammatory cytokines has been proved to be related to both mild cognitive impairment (MCI) and vascular cognitive impairment (VCI). Objective: Find a difference in inflammatory cytokines between MCI and VCI and the possibility to use them as biomarkers to differentiate between them. Methods: Thirty-seven Egyptian patients with variable degree of cognitive impairment were included. Patients were primary selected using the mini-mental state examination. Patients were divided into two groups (MCI) and (VCI) by NINDS-AIREN criteria and MRI brain. Serum was analyzed for CRP, IL-1B, IL-6 and IL-16 and CSF analyzed for IL-1β, IL-6, IL-16. Results: No difference was found in proportion of patients with abnormally elevated serum level of IL-1β, IL-6, IL-16 and C-reactive protein (CRP) between both groups. IL-6 was found abnormally elevated in a higher proportion of patients with MCI compared to patients with VCI. Conclusion: IL-6 elevation in CSF of MCI may be used as a biomarker to differentiate it from VCI. [Egypt J Neurol Psychiat Neurosurg.  2013; 50(2): 195-198]

 Key Words: Mild cognitive impairment, vascular cognitive impairment, cytokines, inteleukin-6.

Correspondence to Shereen Fathi, Department of Neurology, Cairo University, Egypt. Tel.: +201113022610     e-mail:

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