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April2013 Vol.50 Issue:        2        Table of Contents
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Presymptomatic Atherosclerosis: Association with Cardiovascular Risk Factors and Role of Inflammatory Mediators

Asmaa M. Ebraheim1, Abdelazim M. Reda1, Marwa Farghaly1,

Rania M El-hoseiny2, Shaheera El Shafee3

Departments of Neurology1, Critical Care Unit2, Clinical Pathology3; Cairo University; Egypt


Background: During the last decade, compelling experimental and clinical evidence has demonstrated that both systemic and local inflammation might play a prominent role in the pathogenesis of atherosclerosis. Objective: Identify risk factors and possible role of inflammatory mediators in the development of asymptomatic atherosclerosis in carotid and lower extremity arteries. Methods: Thirty subjects aged above 60 years were included. Patients were evaluated clinically with special emphasis on vascular risk factors. All subjects undergone U/S imaging (Doppler for ankle brachial index, Extra- cranial color coded duplex) for calculation of ankle brachial index (ABI) and carotid intima media thickness (CIMT). Moreover, routine laboratory investigations, CRP, levels of soluble intercellular adhesive molecule (sICAM) and vascular cell adhesive molecule (sVCAM) were carried out. Subjects with medical disease that may affect the levels of ICAM and VCAM were excluded from the study. Results: Lower extremities asymptomatic atherosclerosis was associated with diabetes and hypertension (p=0.005 and 0.002 respectively). Both carotid and lower extremities asymptomatic atherosclerosis were significantly associated and correlated with age. Neither of them was associated or correlated with any of the studied inflammatory mediators. Conclusions: Age is an important factor in the development of presymptomatic carotid atherosclerosis, while diabetes and hypertension in addition to increased age are associated with increased risk of development of presymptomatic lower extremities atherosclerosis. The lack of significant association or correlation between CRP and adhesion molecules with presymptomatic atherosclerosis, raises inquiries about the exact role played by inflammatory mediators in the initiation of disease pathology, and emphasizes that this area warrants further research. [Egypt J Neurol Psychiat Neurosurg.  2013; 50(2): 149-156]

 Key Words:  Atherosclerosis, asymptomatic, adhesion molecules

Correspondence to Asmaa M. Ebraheim, Department of Neurology, Cairo University, Egypt. Tel.: +201112399993     e-mail:

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