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April2013 Vol.50 Issue:        2        Table of Contents
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Aquaporin-4 Antibodies in Egyptian Patients with Idiopathic Intracranial Hypertension

Noha T. Abo-Krysha1, Nirmeen A. Kishk1, Laila Rashed2

Departments of Neurology1, Biochemistry2; Cairo University; Egypt


Background: The etiology of idiopathic intracranial hypertension (IIH) is not clear. A dysfunction of the water channels could affect the cerebrospinal fluid (CSF) secretion or absorption and potentially contribute to its pathogenesis. Objective: Is to assess the possible role of Aquaporin (AQP)-4 antibodies in the pathogenesis of IIH. Methods: Eighteen symptomatic IIH patients who were diagnosed according to the updated modified Dandy criteria were selected from the Neurology Department of Kasr El-Aini hospital, Cairo University. Detection of anti-aquaporin antibodies in their CSF samples was measured by ELISA based Assay. Results: The CSF samples of IIH patients were positive for the Aquaporin (AQP)-4 antibody in 16(88.9%) of the patients. The CSF level of AQP-4 antibodies was 15.59±8.03 U/ml. Conclusions: There are two reports investigating the anti-AQP4 antibodies in IIH. Our study contradicted the results of these reports and indicated that AQP4 antibodies have a role in IIH pathogenesis and provided some support for the contribution of inflammatory mechanisms in IIH. [Egypt J Neurol Psychiat Neurosurg.  2013; 50(2): 109-112]

 Key Words: AQP4 antibodies, IIH.

Correspondence to Noha T Abo-Krysha, Department of Neurology, Cairo University, Cairo, Egypt.Tel.: +201010858127        e-mail:

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