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July2007 Vol.44 Issue:        2        Table of Contents
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Study of The Occurrence of Abnormal Involuntary Movements after Cerebral Stroke

Osama M.M.A. Elazouni1, Amal SE Elmotayam1, Karam Selim1, Said A. Elmonem2

Departments of Neurology1, Radiology2, Zagazig University


Introduction: Abnormal involuntary movements (AIM) following cerebral stroke were reported after lesions in certain areas of the brain, but most of these studies were case reports or series of patients with a given type of abnormal movement or anatomical lesion. Aim of The Work: The aim is to study pattern of occurrence of AIM that may occur after cerebral stroke and their relationship to the cause of stroke, clinical and personal data of patients as well as sites of lesions based on imaging studies. Patients and Methods: Thirty four patients with AIM after cerebral strokes were included in this study. These patients were selected suffering first ever clinical stroke, with negative history of previous attacks. These patients were subjected to medical history taking, and thorough neurological examination. The type of AIM was evaluated by more than one of the authors separately with consultation of every case. Clinical follow up of these AIM was done using abnormal involuntary movements scale (AIMS) for detection of improvement or deterioration of these abnormal movements. Also clinical follow up of the motor power, sensory deficits, cerebellar manifestations etc was done. Follow up was done every two weeks in the first month and every month afterward and patients were followed up for at least a year after onset of AIM. Patients that died or did not comply with the study were excluded, also patients with previous history of AIM before onset of stroke were excluded as well. All patients were subjected to CT brain in the acute stage of stroke and those that had normal CT in the acute stage were resubjected to CT or MRI brain. Another 3 cases of central thalamic ischemic lesions, authors came across while doing this research, were included and studied as previously. Results: Thirteen (38.2%) of patients suffered chorea, while only 4 (11.7%) suffered parkinsonism and patients with tremor and dystonia were 9 (26.4%), and 8 (23.5%) respectively. Group of patients with chorea were found significantly (P<0.05) the elder among the other groups. The shortest mean interval time between onset of stroke and development of AIM was that for chorea with statistical significant difference (P<0.05). Most of the patients with AIM were grade 4 and 5 on MRC scale, and of moderate to severe affection of proprioceptive sensation and ataxia. Although lesions of the thalamus and/or basal ganglia were found common in these patients, good percent of patients were found suffering lesions in other areas of the brain. Central thalamic lesion was accompanied with contralateral hypothesis, chorea, and ataxia. Summary and Conclusion: Correlation between site of lesion and type of AIM could be difficult to establish. Although thalamic and basal ganglion lesions are common underlying cause for AIM, these AIM could occur in a good percentage after lesions in other areas of the brain and that could be due to concurrent ataxia and proprioceptive sensory impairment beside reasonable motor strength. Finally, pathogenesis of AIM needs more speculation and more scrutinized analysis of imaging studies with paying more attention to functional brain imaging studies. (Egypt J. Neurol. Psychiat. Neurosurg., 2007, 44(2): 421-435)

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