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July2012 Vol.49 Issue:        3       (Supp.) Table of Contents
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White Matter Microstructure and Cognitive Dysfunction in Systemic Lupus Patients

Hala Mahmoud Haider1, Shereen Zakarya2, Mohammad Abu-Hegazy2

Departments of Physical Medicine, Rheumatology & Rehabilitation1, Ain Shams University;

Neurology2, Mansoura University; Egypt


 Background: Approximately 60% of persons diagnosed with Systemic lupus erythematosus experience neurological complications at some time in the course of their disease. The most common of these neurological complications is neurocognitive abnormality. This study examined white matter structural and metabolic changes of brain in relation to cognition in lupus patients. Methods: Twenty eight systemic lupus patients and twenty sex and age matched healthy controls were included in this study. Magnetic resonance imaging and magnetic resonance spectroscopy were performed and cognitive function was assessed by Mini-Mental State Examination (MMSE). White matter structural and metabolic measures were analyzed and correlated with cognitive function and systemic lupus erythematosus disease activity index. Results: No significant differences were found in total brain grey and white matter volumes or in frontal white matter N-acetyl aspartate/creatine (NAA/Cre) and N-acetyl aspartate/choline (NAA/Cho). Patients had significant increase Choline/Creatine (Cho/Cre) in frontal white matter. About 57.1% SLE patients had cognitive impairment that correlated to higher frontal white matter Cho/Cre and didn't correlate to SLE disease activity index. Conclusions: SLE patients had frontal white matter metabolic changes that correlated with cognitive impairment, whereas no cerebral atrophy or white matter axonal damage was evident. [Egypt J Neurol Psychiat Neurosurg.  2012; 49(3): 199-206]

 Key words: Systemic lupus erythematosus, Cognition, White matter, Magnetic Resonance Spectroscopy.

Correspondence to Hala Haider, Physical Medicine, Rheumatology & Rehabilitation1, Ain Shams University; Egypt.

Tel.: +201008558846. Email:


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