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April2012 Vol.49 Issue:        2        Table of Contents
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Antiepileptic Drugs and Risk of Subclinical Hypothyroidism

Mohamed Abd-Elfattah Yehia1, Sumer Farouk Ahmad1, Abd El-Raouf Omar Abd El-Bakey1, Amal Kamal Helmy2, Mervat Mohamed Abd El-Said Zanaty1


Departments of Neurology & Psychiatry1, Internal Medicine2; El-Minia University; Egypt


 



ABSTRACT

Background: Patients with epilepsy are at considerable risk of subclinical hypothyroidism (SH) .Objective: The aim of our work is to evaluate the possible relation between commonly used antiepileptic drugs (AED) and subclinical hypothyroidism. Methods: The present study included 130 epileptic patients and 50 normal subjects (control group). Patients presented with two or more unprovoked seizures above the age of 18 years, without any neurological, psychiatric or medical disorder other than epilepsy. All the subjects were subjected to full general medical and neurological examination, digital electroencephalogram (only for patients), assessment of subclinical hypothyroidism using the clinical score of subclinical hypothyroidism, laboratory investigations: Such as assessment of thyroid functions TSH, T3, T4 as well as assessment of lipid profile. Results: We found positive correlations between duration of treatment and TSH, cholesterol, triglyceride levels, and the scoring of symptoms and signs of hypothyroidism. There was an increase in TSH levels in epileptic patients receiving polytherapy than monotherapy. Conclusion: It is important to perform routine thyroid function tests and lipid profile for epileptic patients receiving antiepileptic drugs and follow them with scoring of symptoms and signs of hypothyroidism to avoid development of overt hypothyroidism. [Egypt J Neurol Psychiat Neurosurg.  2012; 49(2): 131-136].

Key Words: antiepileptic drugs, subclinical hypothyroidism.

Correspondence to Mohamed Abdel-Fattah Yehia. Department of Neurology, El-Minia University; Egypt.

Tel.: +201112738888     Email: abammo@yahoo.com





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