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April2012 Vol.49 Issue:        2        Table of Contents
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Sexual Dysfunction in Epileptic Male Patients

Ahmed T. El-Ghoneimy1, Mohamed M. Farid2, Maged AbdAl-Naseer1, Hatem S. Mohamed1, Montasser M. Hegazy1, Neveen M. El-Fayoumy3, Husam S. Mourad1

Departments of Neurology1, Andrology2, Clinical Neurophysiology3, Cairo University; Egypt



Background: Hyposexuality is one of the most frequent interictal abnormalities observed in patients with epilepsy. Several factors may disrupt normal sexual function in patients with epilepsy, including psychological influences, hormonal disorders, antiepileptic drugs & the disease itself. Objective: The aim of this work is to study the impact of epilepsy management (monotherapy and polytherapy), duration, frequency and types on male sexual function. Methods: This study was carried out on 90 male subjects (50 epileptics with and 20 epileptics without sexual dysfunction and 20 controls).The International Inventory of Erectile Function (IIEF) questionnaire used to assess the patients, sexual functions, assessment of blood levels of sex hormones, electroencephalography, rigiscan and penile duplex. Results: orgasmic function was significantly lower in frontal lobe epilepsy (FLE) than in temporal lobe (TLE) and generalized epilepsy, SHBG was significantly decreased in TLE compared to other groups, there was a highly significant difference between means of sex hormones and sex hormone binding globulin (SHBG) between epileptic patients with, without sexual dysfunction and control groups and lastly, epileptics on monotherapy with or without sexual dysfunction had a highly statistically significant increase in means of dihydroepiandrosterone sulfate( DHEA) compared to those on polytherapy. Conclusion: Sexual dysfunction was more in TLE patients than both FLE and generalized epilepsy, epileptics with sexual dysfunction had a significant variation in their hormonal assay than those without sexual dysfunction, where testosterone (TT) decreased while estradiol and SHBG were elevated, there was no major difference between monotherapy and polytherapy on sexual dysfunction according to sex hormones and IIEF. [Egypt J Neurol Psychiat Neurosurg.  2012; 49(2): 123-130].

Key Words: Sexual dysfunction – Epilepsy – male – sex hormone binding globulin.

Correspondence to Montasser M. Hegazy, Department of Neurology, Cairo University; Egypt.

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