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April2012 Vol.49 Issue:        2        Table of Contents
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Stem Cell Transplantation in Egyptian Patients with Cerebral Palsy

Mahassen A. Hassan1, Hala Gabr2, Shereen Fathi1, Gihan M. Ramzy1,

Amr H. El-Hassany1, Nirmeen A. Abd El-Ghaffar1

Departments of Neurology1, Clinical Pathology2, Cairo University; Egypt



Background: Stem cell-based therapies have been developed for various CNS diseases including perinatal hypoxic ischemic insults of the brain. Stem cells have the capacity to proliferate in culture, ability to migrate and disseminate following implantation within the adult CNS. Objective: To study the impact of stem cell transplantation (STC) on psychomotor functions in patients with cerebral palsy. Methods: Fifty two Egyptian patients with cerebral palsy were divided into: group I (26 patients who underwent stem cell transplantation) and group II (26 patients who did not undergo stem cell transplantation). Both groups were assessed, initially and after one year, by a group of clinical scales to assess motor, communication and independence skills. Results: In group I, using Boyd’s developmental progress scale revealed a statistically highly significant improvement in motor, independence and communication skills after SCT (P value < 0.01).  Also, 100 points scale revealed a statistically significant improvement after SCT (P value < 0.05). Conclusion: Autologous stem cell transplantation could be a useful tool for the management of patients with cerebral palsy as it may help in improvement of motor, independence and communication skills. [Egypt J Neurol Psychiat Neurosurg.  2012; 49(2): 117-122].

Key Words: Stem cell transplantation, cerebral palsy.

Correspondence to Gihan M. Ramzy, Department of Neurology, Cairo University; Egypt.

Tel.: +201001732028. E-mail: gihanramzy @

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