Online ISSN : 1687-8329


Quick Search 

April2012 Vol.49 Issue:        2        Table of Contents
Full Text

Platelet Activation Markers in Ischemic Cerebral Stroke

Mohamed Y. El-Senousy1, Ehab A. El-Seidy1, Mohamed K. Khalil1, Hazem A. Fayed1, Azza A. Ghali1, Ashraf A. Abo-El Safa1, Mohamed S. Attia2

Departments of Neurology1, Clinical Pathology2, Tanta University; Egypt



Background: Platelet activation is a crucial mechanism in arterial thrombogenesis and therefore in the pathophysiology of ischemic stroke. CD62p and CD63 (platelet activation markers) are expressed exclusively on platelet activation. Objective: To assess serum level of platelet activation markers and its correlation with the course of acute ischemic stroke. Methods: This study included 45 acute ischemic cerebral stroke patients (group I), twenty healthy age and sex matched controls (group II) and 20 risk factor control subjects (group III). CD62p and CD63 were measured in group I on day one, day 14 and day 90 of ischemic stroke onset.  In group I, NIHSS was assessed at same days and correlated with the platelet markers serum level. For groups II and III platelet activation markers level was measured one time only. Results: CD62p was significantly higher in group I on day one after stroke (mean 3.1%) than in groups II and III (mean 1.4% and 1.6% respectively) then it declined on days 14 and 90. CD63 was also significantly high in group I on day one compared with groups II and III (mean 3.1%, 2.9% and 2.7% respectively) and attained high level but without significant difference on days 14 and 90. There was no significant correlation between the NIHSS and CD62p and CD63 levels along the study. Conclusion: Increased platelet expression of both CD62p and CD63 acutely after stroke was followed by a rapid decline in CD62p expression but a persistent increase in CD63 expression under secondary preventive treatment. Whether CD63 is a predictor for recurrent ischemic events has to be investigated in future studies. [Egypt J Neurol Psychiat Neurosurg.  2012; 49(2): 109-115]


Key Words: cerebral ischemia, platelet activation


Correspondence to Ehab A. El-Seidy, Department of Neurology, Tanta University; Egypt.   Tel:+0201116770908

2008 � Copyright The Egyptian Journal of Neurology,
Psychiatry and Neurosurgery. All rights reserved.

Powered By DOT IT