Background:
Platelet
activation is a crucial mechanism in arterial thrombogenesis and
therefore in the pathophysiology of ischemic stroke. CD62p and CD63
(platelet activation markers) are expressed exclusively on platelet activation.
Objective: To assess serum level of platelet activation markers
and its correlation with the course of acute ischemic stroke. Methods: This
study included 45 acute ischemic cerebral stroke patients (group I),
twenty healthy age and sex matched controls (group II) and 20 risk factor
control subjects (group III). CD62p and CD63 were measured in group I on day
one, day 14 and day 90 of ischemic stroke onset. In group I, NIHSS was assessed at same days
and correlated with the platelet markers serum level. For groups II and III
platelet activation markers level was measured one time only. Results: CD62p
was significantly higher in group I on day one after stroke (mean 3.1%) than in
groups II and III (mean 1.4% and 1.6% respectively) then it declined on days 14
and 90. CD63 was also significantly high in group I on day one compared with
groups II and III (mean 3.1%, 2.9% and 2.7% respectively) and attained high
level but without significant difference on days 14 and 90. There was no
significant correlation between the NIHSS and CD62p and CD63 levels along the
study. Conclusion: Increased platelet expression of both
CD62p and CD63 acutely after stroke was followed by a rapid decline
in CD62p expression but a persistent increase in CD63 expression
under secondary preventive treatment. Whether CD63 is a predictor for
recurrent ischemic events has to be investigated in future studies.
[Egypt J Neurol Psychiat
Neurosurg. 2012; 49(2): 109-115]
Key Words: cerebral
ischemia, platelet activation
Correspondence to Ehab A. El-Seidy, Department
of Neurology, Tanta University; Egypt.
E-mail:dr_ehabelseidy@yahoo.com Tel:+0201116770908