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January2012 Vol.49 Issue:        1        Table of Contents
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Influence of Conventional Antiepileptic Drugs on Thyroid Function Tests in Epileptic Children

Mohamed Gomaa1, Yasser Wasel1, Ahmed Mohamed Elewa2

Departments of Neurology1, Clinical Pathology2, Mansoura University; Egypt



Background: Antiepileptic drugs (AED) adverse effects are frequently encountered, careful monitoring for evaluation of adverse effects during AED administration should done as a routine in epilepsy practice. Objective: To determine the changes in thyroid function tests in male children who were under antiepileptic therapy. Methods: This study was carried out in cohort fashion on 42 male children with new onset epilepsy who had not been previously treated with antiepileptic medication. Plasma level of TSH, T3 FT3, T4 & FT4 hormones were measured and compared at baseline and 3 and 6 months after treatment. Results: A total of 42 patients were studied over a period of 6 months. These patients divided into three groups, 15 patients treated with carbamazepine, 15 patients treated with sodium valproate and 12 patients treated with   phenobarbital. The results of our study suggested that the increase in the plasma level of TSH was significant only in the sodium valproate group the plasma level of T3 significantly decrease 3 and 6 months after treatment in the Phenobarbital group while the plasma level of FT3 significantly decreased only in the sodium valproate group. The decrease in T4 plasma level was significant in all groups (Carbamazepine, sodium valproate and Phenobarbital group) 3 and 6 months after the onset of treatment but the decreasing in FT4 plasma level was only significant in the carbamazepine group 6 months after onset of treatment. Conclusion: Phenobarbital had the least effect on thyroid hormones considering the effect such medications on thyroid function test, it necessary to check & test the plasma levels of thyroid hormones periodically after beginning the treatment. [Egypt J Neurol Psychiat Neurosurg.  2012; 49(1): 23-26]


Key Words: Antiepileptic drugs, Epileptic Children, Thyroid Function.


Correspondence to Yasser Wasel, Neurology Department, Mansoura University, 35516 El-Jomhoria St., Mansoura, Egypt.

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