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April2011 Vol.48 Issue:        2        Table of Contents
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Renal Biomarkers in Stroke


Nervana M. Elfayoumy1, Manal M. Kamal2, Dalia R.  Abdel Rahman3


Departments of Neurology1, Clinical and Chemical Pathology2, Internal Medicine3, Cairo University; Egypt



Background: Mild renal insufficiency is increasingly recognized as an independent risk factor for cardiovascular disease and ischemic stroke. Albuminuria  and low glomerular filtration rate (GFR) may contribute to the occurrence of  stoke and hemorrhagic transformation. Objective: Is to investigate the relation between the clinical and radiological parameters of stroke and certain biomarkers for early renal impairment (creatinine, estimated GFR, albuminuria, and potassium). Methods: This study was conducted on 19 stroke patients and 11 normal controls. The subjects were submitted to: Neurovascular examination, renal functions tests including: serum creatinine, blood urea, serum albumin, serum Na+, K+, detection of  micro and macroalbumin in urine and estimated glomerular filtration rate (GFR). Duplex studies and MRI, CT brain were done. Results: The median of microalbuminuria in patients was increased more than controls (61 versus 15 ug/mg creatinine) and about 52.6% of patients had albuminuria. Significant correlation was found between albuminuria and duration of illness. Patients with hemorrhagic lesion and posterior circulation infarcts showed increased  level of albuminuria and low eGFR. Hypertensive and diabetic patients showed increased level of albuminuria but not reaching the significant level. Conclusion: There is strong evidence that albuminuria is  linked to stroke especially hemorrhagic with long standing illness and in  hypertensive and diabetic patients. We suggest that stroke patients with elevated albuminuria may especially benefit from more intensive vascular risk reduction. [Egypt J Neurol Psychiat Neurosurg.  2011; 48(2): 177-181]


Key Words: Stroke, Renal insufficiency, Albuminuria, GFR.


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