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April2011 Vol.48 Issue:        2        Table of Contents
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GABA (B) Receptor-1 Gene Variation and Temporal Lobe Epilepsy

Rasha H. Soliman1, Mona Nasser2, Magdy K. Mohamed3


Departments of Neurology1, Clinical & Chemical Pathology2, Radiology3, Beni Suef University; Egypt




Background: γ-aminobutyric acid (GABA) receptor genes are prime candidates for a role in seizure susceptibility. Objective: To examine the association between the G1465A GABA (B)1 receptor gene polymorphism and mesial temporal lobe epilepsy susceptibility. Methods: Fifty patients with mesial temporal lobe epilepsy [11 (22%) patients with hippocampal sclerosis (HS) and 39 (78%) without HS] and 30 normal unrelated subjects were included in this study. Patients were assessed using clinical evaluation, EEG and MRI-brain. Polymerase chain reaction and restriction fragment length polymorphism were used to genotype patients and normal subjects for the polymorphism G1465A. Results: The A/G genotype was present significantly in 6 patients (12%) and absent in all control subjects, rest of patients and all controls exhibited the wild G/G genotype. Patients with AG genotype had earlier age of onset and a more severe disease, whereas presence of family history of epilepsy or history of febrile convulsions and presence or absence of hippocampal sclerosis were not higher in patients with A/G genotype. Conclusion: Our results indicate that polymorphism G1465A of the GABA (B) R1 gene could be a genetic risk marker for the development of temporal lobe epilepsy. [Egypt J Neurol Psychiat Neurosurg.  2011; 48(2): 123-128]


Key Words: Temporal lobe epilepsy, GABA (B) receptor-1, Gene polymorphism


Correspondence to Rasha Hassan Soliman, Department of Neurology, Beni Suef University, Egypt.

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