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January2011 Vol.48 Issue:        1        Table of Contents
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Serum Leptin and Leptin Gene Polymorphism in Idiopathic Intracranial Hypertension

Mona AF. Nada1, Yasmine T. El Shiwy2, Riham A. El Essawy2, Marwa M. Sheta2,

 Reham A. Zeyada2, Mona A. Abu Al Hassan2

Departments of Neurology1, Chemical Pathology2, Cairo University; Egypt



Background: Several mechanisms have been suggested for idiopathic intracranial hypertension (IIH). Only few studies have been performed to study the relation between serum Leptin and IIH. Objective: To evaluate the relationship between obesity and idiopathic intracranial hypertension by exploring the role of serum leptin level and the frequency of -2548G/A LEP gene. Methods: This is a case-control prospective study which included 30 patients (Group I) with idiopathic intracranial hypertension and 2 matched control groups (Group II; 20 obese - Group III; 10 lean). Serum leptin levels determined by ELISA, and PCR RFLP carried out for -2548G/A LEP gene polymorphism analysis were done for all participants. Results: Leptin level varied significantly on comparing either Group I or II with Group III (p<0.001). Twelve patients were carriers of mutant (A) allele (17 out of 60 alleles, 28%) while only 5 found in group II (6 out of 60, 10%) and none in group III with a statistically significant difference in allele frequency (p=0.02) OR of 3.558 (95% CI 9.801-1.292) found on comparing allele frequency of cases versus controls. A statistically significant difference (p=0.02) with OR 3.558 (95% CI 9.8-1.29) was found when serum leptin level of mutant (A) allele carriers was compared to that of wild (G) allele carriers in patients. Conclusion: Elevated serum Leptin levels and -2548G/A LEP gene polymorphism could be considered to be associated with increased risk of developing IIH. [Egypt J Neurol Psychiat Neurosurg.  2011; 48(1): 57-62]


Key Words: Idiopathic intracranial hypertension (IIH), Leptin, Leptin gene polymorphism, Obesity, Body Mass Index.



Correspondence to Mona AF. Nada. Department of Neurology, Cairo University, Egypt. Tel.: 0020189288848     E-mail:

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