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July2010 Vol.47 Issue:        3       (Supp.) Table of Contents
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Serum Tumor Necrosis Factor Alpha Concentration in Children with Guillain Barré Syndrome: Correlation with Clinical Disability and IVIG Therapy

Sabry M. Abdeldayem1, Eman M. Awad2, Wael R. Hussein3,

Ghada R. Mousa4, Ayman M. Selim4

 

Departments of Neurology1, Tanta University; Neurology2, Anesthesia3, Ain Shams University;

Neurology4, Zagazig University; Egypt

 



ABSTRACT

Background: Guillain-Barré syndrome (GBS) is an acute autoimmune post-infectious demyelinating polyradiculoneuropathy. Activated T lymphocytes and macrophages are the principle source of cytokines, including TNF-α ;a primary mediator of inflammation. There is evidence that TNF-α is capable of inducing selective and specific damage to myelin in vitro. Objectives: To assess the role of TNF-α in the pathogenesis of GBS and correlate its serum level with clinical disability and IVIg therapy. Subjects and Methods: Twenty patients presented by acute GBS with established clinical criteria for diagnosing  GBS were recruited. Twenty age and sex matched healthy control subjects were also studied. All patients were submitted to thorough history taking, including demographic data and antecedent events, neurological examination and neurophysiological tests were performed.  IVIg was given to all patients within the first week after admission. The patients were followed up for 6 months. The outcome of all patients was determined. Results: Serum TNF-α concentration in the 20 GBS patients with elevated levels showed a steady decline from (21.43 to 14.18 pg/ml) following treatment with IVIg. At the time of discharge from the hospital, there was a positive correlation between neurological disability  and level of  TNF- α concentration in these 20 GBS patients. Conclusion: The results of this study indicate that elevated serum level of TNF-α occur in a proportion of patients with GBS and in these patients elevated serum TNF-α level declines with IVIg therapy. [Egypt J Neurol Psychiat Neurosurg.  2010; 47(3): 519-525]

 

Key Words: Tumor necrosis factor alpha, Guillain Barré syndrome, Children, IVIg.

 

 

Correspondence to Sabry Abdeldayem. Department of neurology, Tanta University, Egypt.

Tel: +20109880389.     Email: sabryneuro@yahoo.com.

 





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