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July2010 Vol.47 Issue:        3       (Supp.) Table of Contents
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Efficacy of Repetitive Transcranial Magnetic Stimulation in the Management of Obsessive Compulsive Disorder

Adel A. Badawy, Hosam El Sawy, Mohammed Abd El Hay


Neuropsychiatry Department, Tanta University; Egypt



Background: Obsessive-compulsive disorder (OCD) is a debilitating condition that affects approximately 1% to 3% of the world population. The primary treatments are selective serotonin reuptake inhibitors and behavioral therapy. Despite therapy, approximately 30% to 40% of patients continue to suffer from disabling OCD symptoms. Objective: is to evaluate the efficacy of repetitive transcranial magnetic stimulation (r-TMS) in management of OCD patients, either as monotherapy or as add-on treatment in patients with poor response to selective serotonin reuptake inhibitors (SSRIs). Methods: The present study included sixty OCD patients. Forty patients were none medicated; twenty of them (randomly selected), received sham stimulation as a control group and the other twenty received real r-TMS. The third group included twenty patients with poor response to SSRIs; they received real r-TMS. The results of the three groups were compared pre and post treatment. Results: While r-TMS was not effective as a single treatment for OCD patients, it was effective as add-on treatment for OCD patients. The use of r-TMS induced a statistically significant increase in the value of motor threshold (MT) in the active group of patients (both Monotherapy and add-on treatment groups) after receiving 15 sessions of real r-TMS; this means that TMS lowered the hyperexcitable circuits in OCD. [Egypt J Neurol Psychiat Neurosurg.  2010; 47(3): 393-398]


Key Words: Obsessive-compulsive disorder, transcranial magnetic stimulation

Correspondence to Adel A. Badawy. Department of Neuropsychiatry, Tanta University, Egypt.

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