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July2010 Vol.47 Issue:        3       (Supp.) Table of Contents
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Assessment of Cognitive Functions in Children with Chronic Renal Failure

Nihal El-Shazly1, Happy Kaysar2, Ashraf Adel3

 

Departments of  Clinical Neurophysiology1, Pediatrics2, Psychiatry3, Cairo University; Egypt

 



ABSTRACT

Background: Chronic Kidney disease (CKD) is associated with cognitive impairment. The relation between the degree of cognitive decline and severity of chronic kidney disease (CKD) is less well understood. Objective: assessment of the cognitive functions of children with CKD in comparison to age and sex matched controls as well as in relation to the degree of renal impairment, as determined by the glomerular filtration rate (GFR), subjectively by psychological assessment and objectively by ERP. Methods: In this study 25 neurologically asymptomatic children suffering from CKD of variable severity and duration were enrolled. Besides this, 25 healthy controls were also studied. Glomerular filtration rate (GFR) was estimated using the Schwartz formula. The P300 was studied in all subjects by using standard auditory ‘odd-ball’ paradigm. Stanford –Binet intelligence scale was performed. Results: We noted a significant prolongation of P300 latencies as severity of CKD increased. Duration of illness, hemoglobin level, and serum electrolytes were not correlated  with P300 latency. Conclusion:  Increasing severity of CKD is associated with progressive  cognitive decline that can be recognized early by monitoring of P300. [Egypt J Neurol Psychiat Neurosurg.  2010; 47(3): 387-391]

 

Key Words: chronic renal failure; cognitive function; event-related potentials.

 

Correspondence to Nihal El-Sahzly, Department of clinical neurophysiology, Cairo University, Egypt. Tel : +235719406/ Mobile: +20126767976. Email: nihalelshazly@yahoo.com





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