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July2010 Vol.47 Issue:        3       (Supp.) Table of Contents
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High Sensitivity C-Reactive Protein and its Gene Polymorphism in Acute Ischemic Stroke

Rasha H. Soliman1, Noha A. Abdel-Monem1, Azza A. Helmy2, Sanaa Abd El-Shafy3

 

Departments of Neurology, Beni Sueif University1, Cairo University2;

Clinical Pathology3, Beni Sueif University; Egypt

 



ABSTRACT

Background: Elevated C-reactive protein (CRP) level is considered to be a predictor of ischemic stroke and CRP genetic polymorphism is reported to be associated with elevated CRP level. Objective: The aim of this work was to study the relation between high sensitivity CRP (hs-CRP) as well as CRP gene polymorphism and ischemic stroke. Methods: Forty-one ischemic stroke patients and forty normal subjects were included in this study. Patients were evaluated clinically and radiologically. Laboratory investigations, hs-CRP assay and genetic testing of CRP gene were done for both patients and control groups. Results: Serum hs-CRP level was significantly high in ischemic stroke patients compared to control subjects and high CRP level was significantly associated with male gender, hypertension, D.M, hyperlipidemia, total anterior circulation syndrome (TACI), large sized infarction on CT examination and poor stroke outcome. In human CRP G1059C polymorphism genotype, GG allele was the most common one in both patients and control groups (95%, 100%) with no significant difference, as GC allele is less common (only two patients), and CC allele was absent in both groups, with no significant association between GG allele and high hs-CRP. Conclusion: hs-CRP level is elevated in acute ischemic stroke and it is intimately associated with different vascular risk factors and prognostic factors. Human CRP G1059C polymorphism especially GG allele did not influence the serum level of hs-CRP and did not show any association with ischemic stroke. [Egypt J Neurol Psychiat Neurosurg.  2010; 47(3): 373-379]

 

Key Words: Ischemic stroke – High sensitivity C-reactive protein – Polymorphism.

 

Correspondence to Rasha Hassan Soliman, Department of Neurology, Beni Sueif University, Egypt.

Tel: +20123374563.  Email: dr.rashasoliman@windowslive.com





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