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July2010 Vol.47 Issue:        3       (Supp.) Table of Contents
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Management Challenges in Oromandibular Dystonia: The Role of Botulinum Toxin-A

Mohamed S. El-Tamawy, Hatem Samir

 

Department of Neurology, Cairo University; Egypt

 



ABSTRACT

Background: Oromandibular dystonia is a focal or segmental cranio-cervical dystonia, with diverse incapacitating clinical manifestations. Though botulinum toxin injection has emerged as an effective symptomatic treatment; yet, many unanswered questions are not addressed by the current available studies. Objective: To evaluate the efficacy of Botulinum toxin type A (BTX-A) treatment in patients with oromandibular dystonia. Methods: This prospective study included 13 patients with refractory oromandibular dystonia, who were followed up for 3 months. All patients were videotaped according to Dystonia Study Group Videotape examination protocol before and after injections. Injection technique was based on clinical observation coupled with electromyography. Primary outcome measure was the global impression scale (GIS), and secondary outcome measure was quantified according to Unified Dystonia Rating Scale (UDRS). Results: Patients showed improvement of both primary and secondary efficacy measures, maximum satisfactory responses were detected at the 4th week after injection. This improvement was maintained till the end of the study visits (12th week), and we could not detect any adverse events. Conclusion: BTX-A is considered an effective and safe treatment option for refractory OMD. [Egypt J Neurol Psychiat Neurosurg.  2010; 47(3): 347-354].

 

Correspondence to Mohamed S. El-Tamawy, 176 El-Tahrir St. – Babellouk – Down town, Cairo, Egypt.

E-mail: eltamawy@hotmail.com.





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