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April2010 Vol.47 Issue:        2        Table of Contents
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Migraine and Cerebrovascular Stroke: Risk Factors and Outcome

Mohamed E. Elwan, Ahmad M. Elshereef, Rasha A. Elkapany, Hosna S. Soliman


 Department of Neuropsychiatry, Minoufiya University; Egypt



Background: The relationship between migraine and cerebro-vascular stroke is extremely complex and bidirectional. Objective: This study aimed to determine whether migraine is a risk factor for stroke; the characteristics, degree of disability and prognosis of acute stroke in patients with migraine. Methods: This study was carried out on 40 patients suffering from stroke. They were compared with another 40 persons as a control group. Each group was divided into two subgroups (migrainous and non-migrainous). Each patient was subjected to thorough medical and neurological history taking, complete general and neurological examination, routine work up for stroke risk factors, and CT scan brain. Severity of stroke was assessed by using clinical outcome scales {National Institute of Health Stroke Scale (NIHSS) and Barthel Index}; at onset and every two weeks for eight weeks. Results: There was a statistically significant difference between stroke patients and control group regarding history of migraine (25% versus 12.5%), but there was no significant difference regarding type of migraine. History of migraine was associated with increased risk of stroke with no significant difference regarding type of stroke (ischemic or hemorrhagic) and type of migraine.  There was a statistically significant difference between migranous and non-migranous stroke patients as regard outcome. Migrainous stroke patients show better outcome than non-migrainous at different follow up visits regarding results of Barthel index but not with NIHSS score. Conclusion: History of migraine was associated with increased risk of stroke. However; migrainous stroke patients showed better outcome than non-Migrainous. (Egypt J Neurol Psychiat Neurosurg.  2010; 47(2): 337-344)


Key Words: migraine, stroke, outcome

Correspondence to Ahmad M. Alshereef, Department of Neurology,  Minoufiya University; Egypt. Tel.: +20109818581. Email: alshereef 1969 @

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