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April2010 Vol.47 Issue:        2        Table of Contents
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Neuropsychiatric Disorders and Sleep Disturbances in Patients with Parkinson's Disease

Mohamed E Elwan, Nabil R Mohamed, Wafik M El Shaikh,

Ahmad M ELShereef, Mohamed R. Soltan


Department of Neurology, Minoufiya University; Egypt



Background: Patients with Parkinson’s disease (PD) have wide range of neuro-psychiatric symptoms and sleep disturbances as well as the motor manifestation of the disease.  Several non-motor features of PD have attracted attention of physicians as these features have been correlated with the quality of life of the patients. Objective: is to evaluate the extent of neuropsychiatric disorders and sleep disturbances in patients suffering from PD. Methods: This study include 30 patients suffering from PD (13 males and 17 females), compared with 20 healthy subjects age and sex matched as a control group. Patients were diagnosed as having PD using Parkinson’s Disease Society Brain Bank Diagnostic Criteria (PDSBBDC). All patients were subjected to full history taking and neurological examination, MMSE (Mini-mental state examination), Semi-Structured clinical interview (SCID-1) based on DSM-IV, and sleep questionnaire of Asaad and Kahla. Results: The most common psychiatric disorders in PD patients were depression (60%), anxiety 43.3%, and psychosis in 20%. The difference between patients and control groups was significant as regarding depression but not significant for others. The most common sleep disorders were nocturia (40%), sleep maintenance problem (26.7%), and bad quality of sleep (23.3%). All sleep disorders were higher in patients than in control group. Different types of psychiatric disorders sleep disorders were higher in L- Dopa receivers than in L- Dopa non-receivers. Conclusion: There were significant neuropsychiatric and sleep disturbances in patients with Parkinson's disease which were higher in L- Dopa receivers than in L- Dopa non-receivers. (Egypt J Neurol Psychiat Neurosurg.  2010; 47(2): 317-324)


Key Words: Parkinson’s, neuropsychiatric, sleep.

Correspondence to Ahmad M. Alshereef, Department of neurology, Minoufiya University; Egypt. Tel.: 0020109818581, Email: alshereef1969 @

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