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July2005 Vol.42 Issue:        2        Table of Contents
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Clinical, Electrophysiological and Histopathological Diagnosis of Chronic Polyradiculoneuropathy

Hamdy N.A. El-Tallawy1, Essam S. Darwish1, Samyaa Ashour2, Seyam S. Salem3, Hesham S. Atta4, Tarek A. Rageh1
Departments of Neurology, Assiut University1, Neurology, Ain Shams University2,Clinical Neurophysiology, Cairo University3, Pathology, Assiut University4

ABSTRACT

Peripheral neuropathies are among the most common neurological diseases. They are either inherited or acquired and are often associated with various disorders. This study was designed to 1- Evaluate the role of conventional and non-conventional neurophysiological studies in diagnosis of chronic polyneuropathy and 2- Evaluate the role of histopathologic study for diagnostic purposes.This study was carried out in the Neurology Department, Assiut University Hospital. The study was performed on 25 consecutive patients (20 males and 5 females) who were admitted to our department over the period of one year (May 1st 2002- April 30th, 2003). They were presented with manifestations of chronic polyneuropathy with duration of illness more than 6 months. Also,  the study included age and sex matched 20 normal control individuals (14 males and 6 females).All patients and control were subjected to:A-Complete history taking and clinical examination.B-  Neurophysiological studies including (Distal latency, Nerve conduction, F response, H reflex, Conduction block study, and Quantitative electromyography) C- Sural nerve biopsy for patient group only. Patients were classified according to clinical and neurophysiological data in to 3 groups; Chronic inflammatory demyelinating polyneuropathy (CIDP), Hereditary polyneuropathy, and Polyneuropathy of undetermined aetiology. Comparison between three studied groups revealed; a statistical difference in the CMAP amplitude of ulnar nerve  being more reduced in CIDP and those of undetermined aetiology compared to hereditary group. Conduction block were found mainly in CIDP group.Sural nerve biopsy revealed segmental demyelination, axonal degeneration, active remyelination, axonal sprouting, and necrotizing vasculitis in different percentage among the three studied groups.

(Egypt J. Neurol. Psychiat. Neurosurg., 2005, 42(2): 493-503).

 





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