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July2005 Vol.42 Issue:        2        Table of Contents
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Event Related Potentials and Cognitive Functions in Egyptian Euthemic Bipolar Patients

Samia Abd Al-Rahman1, Mostafa R. Raslan1, Ann Ali Abd Alkader2, Noha Sabry1, Mona Mohammed Nada2, Maha Emad Al-Din1
Departments of Psychiatry1, Clinical Neurophysiology Unit2, Cairo University


Few studies have attempted to investigate cognitive and neurophysiological states in bipolar patients during periods of remission. This study was done to test the hypothesis that euthymic bipolar patients have persistent cognitive and neurophysiological impairment. 20 euthymic bipolar patients as diagnosed according to DSM-IV criteria of diagnosis were compared with 20 controls as regards cognitive functions and evoked related potential. The following tools were applied: Hamilton Rating Scale for Depression, Young Mania Scale, WAIS and WCST, in addition to measuring event related potential (P300 latency and amplitude). Our results revealed a generalized rather than selective impairment, in addition to impairment in executive functions, along with impairment in word fluency, which would suggest prefrontal pathology in bipolar patients. The number of episodes, the longer duration of illness and the positive family history of psychiatric disorders were found to be important risk factors of such impairments. Patients showed also prolonged P300 latency and reduction in amplitude which was correlated with some of the neurocognitive subtests and with the number of episodes. We conclude that there is some degree of neurocognitive and neurophysiological impairment in euthymic bipolar patients. This needs further investigations.

(Egypt J. Neurol. Psychiat. Neurosurg., 2005, 42(2): 377-390).


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