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July2005 Vol.42 Issue:        2        Table of Contents
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Clinical Pattern, MRI and Serum Soluble Intercellular Adhesion Molecule-1 (sICAM-1) in Neuro-Behcet Disease

Adel S. Abdel-Ghaffar1, Dorriya Abdul-Fattah1, Alaa M. Abdel-Ghani1, Mohamad A. Denewar2, Somaya M. Desouky3
Departments of Neurology1, Radiology2, Microbiology & Immunology3, Zagazig Universit


Behcet’s disease is a chronic multisystem disease. Neurological manifestations are relatively rare, but they must be investigated due to their grave prognosis. We designed this study to measure serum level of sICAM-1 in patients with neuro-Behcet disease, and investigate the possible relationship between its level, clinical activity of the disease and MRI findings. Twenty-three patients presenting with neuro-Behcet disease participated in this study. They were divided into two groups according to clinical course of the disease: group I, comprised 15 patients with relapse/remission course; group II, comprised 8 patients with progressive course. Serum sICAM-1 level was determined using ELIZA technique at two occasions (before and after treatment) for all patients. The levels were compared with those of 20 control healthy subjects age and sex matched. All patients underwent MRI brain examination for 2 times at corresponding dates for serum analysis of sICAM-1. Similarly, clinical evaluation of patients including the disability status scale was performed at the same occasions. Our patients ages ranged from 25-53 years( mean33.5±10.3) of whom 21 were males(91%) and 2 were females(9%).The mean serum sICAM-1 level was significantly higher in group I and group II patients on admission (375.4±67.4ng/ml and 278.75±41.4ng/ml respectively) than in the control group (205.8±36.6ng/ml). The serum level of sICAM-1 showed significant reduction in group I patients after treatment (remission phase) than before treatment (relapse phase) p<0.001, while in group II patients the reduction in its level did not reach statistical significance p=0.18. MRI brain revealed abnormal findings in all patients, demonstrated as extensive regions with high intensity signals on T2 weighted images. There was closely related association between MRI findings (size and number of lesions), serum levels of sICAM-1and clinical activity of the disease, in which clinically evident remission was associated with reduction in both serum levels and MRI findings. We concluded that both sICAM-1 and MRI study may be useful in assessing disease activity as well as in monitoring response to treatment.

(Egypt J. Neurol. Psychiat. Neurosurg., 2005, 42(2): 279-289).


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