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July2005 Vol.42 Issue:        2        Table of Contents
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Light Chain Immunoglobulins in Patients with Systemic Lupus Erythematosus and Central Nervous System Involvement

Adel S. Abdel-Ghaffar1, Magdy A. Aidaros1, Mohamed G. Aodalla2

Departments of Neurology1, Bacteriology2, Zagazig University


This study was done on 15 patients with systemic lupus erythematosus ( SLE) and central nervous system (CNS) involvement (CNS – SLE) (group 1), Eight patients with SLE without CNS involvement (group II) and 10 normal control subjects (group III). Clinical assessment, radiological and routine laboratory investigation were done, in addition to determination of light chain immunoglobulin kappa (k) and lambda (L) before and after treatment. There was statistical significant elevation of both Igk and IgL indices in group I compared to group II and group III ( P <0.05) and both indices correlated well with each other in group I. There was statistical significant decrease of both Ig k and IgL indices when the CNS manifestation subsided after medical treatment in group III. These observation suggestive that serum free light chain immunoglobulins measurements will be of considerable benefit for diagnosis and disease management.

(Egypt J. Neurol. Psychiat. Neurosurg., 2005, 42(2): 273-278).


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