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July2007 Vol.44 Issue:        2        Table of Contents
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Serum Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) in Acute Ischemic Stroke

Ayman Nassef, Nagia Fahmy, Naglaa El-Khayat, Hala El-Khawas, Yousry AboElnaga

Department of Neurology, Ain Shams University

ABSTRACT

 

Background: Neuroinflammatory mechanisms play an important role in ischemic injury and interruption of these processes can result in improved neurological outcomes. Firm adhesion of leukocytes to the endothelial cells as well as leukocyte activation and transmigration across the endothelium is mediated by adhesion molecules. Aim of The Work: We aimed to assess the levels of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) in acute stroke and  their correlation to the extent of  neurological deficits and short term  clinical outcome. Subjects and Methods: Forty four  patients with first ever acute ischemic stroke admitted within 72 hours of stroke onset were enrolled, in addition to eighteen normal controls and twelve patients with vascular risk factors matched with age and sex to the patients group. Blood samples were obtained from the patients at the third day of stroke onset  and from the  control groups  and  subjected to the measurement of the level  of sVCAM-1  in the serum. Results: There is a higher mean sVCAM-1 among patients with ischemic stroke compared to normal controls and the difference is highly significant statistically, P<0.01. There is a higher mean sVCAM among patients with large vessel disease compared to patients with small vessel disease and the difference is highly significant statistically, P<0.01. There is a highly significant positive correlation between sVCAM-1 and NIHSS score, P<0.01. Also we found a statistically significant  negative correlation between Barthel Index Score and sVCAM-1, P<0.05. Conclusion: The results support the prior hypothesis of involvement of the adhesion molecules (VCAM-1) in the pathogenesis of acute cerebral ischemia and their impact on neuronal damage and neurological deficit. Therapeutic trials that attempt to interfere with the function of adhesion molecules could be of benefit in acute stroke management.

(Egypt J. Neurol. Psychiat. Neurosurg., 2007, 44(2): 771-779)

 





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