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July2007 Vol.44 Issue:        2        Table of Contents
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An Electro-Physiologic Study of Trigeminal Brainstem Circuits in Migraine

Nihal El-Shazly1, Fouad Abd Allah2, Hanan Hosni1, Gihan Ramzy2, Mona T. El-Ghoniemy3

Departments of Clinical Neurophysiology1, Neurology2, Neurosurgery3, Cairo University


Objective: The study aimed at investigating functional changes in the trigeminal and optic nerves brainstem connections in migraine patients. Methods: Trigeminal somatosensory evoked potentials (TSER's), electric blink reflex (EBR) and light stimulus evoked blink reflex (LBR) were carried out interictally on 18 patients suffering from migraine without aura and 12 healthy controls. TSER’s latencies (N1, P1, N2, and P2), EBR latencies (R1, ipsilateral and contralateral R2) as well as LBR latencies (direct and indirect responses) and their amplitudes were recorded and compared to healthy controls. Results: The ipsilateral and the contralateral R2 components of the EBR (R2i, R2c) showed a highly significant delay as compared to the control group (p<0.000). N1, P1 and N2 latencies in patients were significantly longer than the control group bilaterally. P1 latencies showed the most significant prolongation of latency (p<0.0000). The latencies of the LBR direct and indirect responses were significantly prolonged in the patient group (p<0.000) and had a double fold amplitude compared to those of the control group. Conclusion: Migraine patients show a disruption in the central circuits not only at the level of the brainstem but possibly within the higher cerebral regions as well.

(Egypt J. Neurol. Psychiat. Neurosurg., 2007, 44(2): 693-703)



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