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January2005 Vol.42 Issue:        1        Table of Contents
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Motor and Visual Cortical Excitability in Migraineurs with or without Aura Using Transcranial Magnetic Stimulation

Eman M. Khedr, Mohamed A Ahmed 1, Khaled A Mohamed1, Effet M Awad2
Departments of Neuropsychiatry1, Physiology2, Assiut University



Background and purpose of study: Visual and motor cortical excitability in migraineurs were controversy, some favoring increased, others decreased interictal excitability. The aim of this work was to study the motor and visual cortical excitability in migraineurs between attacks. Patients and Methods: Twenty–eight migraineurs patients, 18 with visual aura and 10 patients without aura and twenty healthy right-handed, age and sex matched volunteers were included in the study. Each subject was submitted to the following: determination of resting motor threshold (rMT), cortical silent period (CSP), MEP input-output curves and phosphene threshold (PT). Results:  Significant lower rMT, shorter CSP, increased MEP recruitment in migraineurs were recorded compared with the control group. There was an increased prevalence of phosphene (85%) as well as lower PT (63% of the stimulator output) in migraineurs compared with control group (75%, and 72% respectively). No significant differences between patients with aura and those without aura in different parameters of cortical excitability. There was a significant negative correlation between duration of illness and phosphene threshold (P = 0.02). Conclusion: Our findings confirm that the motor and visual cortexes are hyperexcitable and this appears to be consequent upon a failure of inhibitory circuits in migraineurs.

(Egypt J. Neurol. Psychiat. Neurosurg., 2005, 42(1): 9-16).


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