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July2006 Vol.43 Issue:        2        Table of Contents
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MRI Biomarkers in Mild Cognitive Impairment and Alzheimer Disease

Y. Abo El-Naga, M. F. EL-Shater2,A. Gaber1, Sohair A. A. Hindawi3, T. M El-Gammal2

Departments of Neurology1, Radiology3, Ain Shams University, Neurology2, Tanta University



Background: Recently there has been increased interest in identifying patients at the earliest stages of Alzheimer disease (AD), so that effective treatment (when this is developed) can be initiated at an early stage. Therefore, neuroimaging studies have been performed on non-demented subjects who are at increased risk for AD, including family history of AD and non-demented patients with mild cognitive impairment (MCI). Objectives: Our purpose was to use volumetric MR imaging to explore the extent of atrophy of the volumes of two temporal lobe structures, the entorhinal cortex (ERC) and the hippocampus, in patients with AD and MCI compared with normal cognition (NC) and to determine the powers of the ERC and the hippocampus for discrimination between these groups. Subjects and Methods: This study included 42 subjects with NC, 32 patients with MCI, and 36 patients with AD. Volumes of the ERC and hippocampus were measured based on coronal T1 weighted MR images.  Results: Both ERC and hippocampal volumes were reduced in MCI (ERC 13%, hippocampus 11%, p<0.05) and AD (ERC 41%, hippocampus 30%, p<0.01) compared with NC. Furthermore, AD showed greater volume loss in the ERC than in the hippocampus (p<0.01). There was a significant correlation between ERC and hippocampal volumes in MCI and AD (both p<0.001), but not in NC. Using ERC and hippocampus together improved discrimination between AD and NC but did not improve discrimination between MCI and NC. The ERC was better than the hippocampus for distinguishing MCI from AD. Conclusion:  Volume reduction in the ERC and hippocampus may be early signs of AD pathology that can be measured using MRI.

(Egypt J. Neurol. Psychiat. Neurosurg., 2006, 43(1): 563-574)


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